Sex cord-stromal tumors of the ovary are a heterogenous group of relatively rare neoplasms arising from hormone-producing cells of ovarian cortical stroma. They make up approximately 8% of all ovarian tumors and are the most common ovarian tumors with endocrine manifestations. WHO Classification subdivides them into 3 main categories based on the predominant cell types. Pure stromal tumors have a mesenchymal appearance and include: fibroma, cellular fibroma, thecoma, luteinized thecoma with sclerosing peritonitis, sclerosing stromal tumor, microcystic stromal tumor, signet-ring stromal tumor, Leydig cell tumor, steroid cell tumor, and fibrosarcoma.Pure sex cord tumors have an epithelioid appearance and include: adult granulosa cell tumor, juvenile granulosa cell tumor, Sertoli cell tumor, and sex cord tumor with annular tubules.Mixed sex cord-stromal tumors include Sertoli-Leydig cell tumor, sex cord-stromal tumor, NOS, and gynandroblastoma.The most common sex cord-stromal tumors are tumors in fibroma-thecoma group (80-85%) followed by granulosa cell tumors (10-15%). The remainder are quite rare. Most of the clinically malignant tumors are granulosa cell tumors. References:1. Mutter G. L.& Prat J (2014). Pathology of the Female Reproductive Tract - 3rd Edition. Churchill Livingstone Elsevier.2. WHO Classification of Tumors. Female Genital Tumors. 5th Edition, 2020; IARC, Lyon, France.3. Nucci MR, Parra-Herran C (2021). Gynecologic Pathology. 2nd Edition. Philadelphia, PA. Elsevier.4. Goldblum, J. R. et al (2018). Rosai and Ackerman's Surgical Pathology - Eleventh Edition. Philadelphia, PA. Elsevier. 5. Selected review articles as mentioned in individual entities.
%2Fcase%2Fdetail_images%2Fc6582_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6583_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6584_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6585_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6586_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6587_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6588_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6589_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6590_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6591_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6592_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6593_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6594_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6595_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6596_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6597_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6598_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6599_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6600_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6601_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6602_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6603_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6604_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6605_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6606_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6607_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6608_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6609_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6610_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6611_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6612_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6613_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6614_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6615_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6616_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6617_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6618_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6619_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6620_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6621_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6622_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6623_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6624_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6625_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6626_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6627_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6628_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6629_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6630_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6631_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6632_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6633_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6634_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6635_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6636_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6637_detail.png&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6638_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6639_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6640_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6641_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6642_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6643_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6644_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6645_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6646_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6647_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6648_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6649_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6650_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6651_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6652_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6653_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6654_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6655_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6656_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6657_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6658_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6659_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6660_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6661_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6662_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6663_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6664_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6665_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6666_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6667_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6668_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6669_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6670_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6671_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6672_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6673_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6674_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6675_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6676_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6677_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6678_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6679_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6680_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6681_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6682_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6683_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6684_detail.jpg&w=384&q=75)
%2Fcase%2Fdetail_images%2Fc6685_detail.jpg&w=384&q=75)