Image Description
Differential Diagnosis of Adult Granulosa Cell Tumor (GCT) of Ovary: continued from prev. image
Endometrial Stromal Sarcoma (ESS): Features favoring ESS include bilateral tumors, lack of endocrine manifestations, arteriolar vascular pattern, pericellular reticulin fiber network, and lack of staining with alpha-inhibin, FOXL2 and calretinin.
Undifferentiated Carcinoma: The diagnosis of undifferentiated carcinoma over adult GCT is favored by: nuclear hyperchromasia and pleomorphism, atypical mitoses, and absence of nuclear grooves. Adult GCT is positive for FOXL2, alpha-inhibin, calretinin, vimentin and negative for EMA. Adult GCT is confined to the ovary at presentation and has uniform nuclei with grooves.
The image shows ESS within vascular spaces.
Endometrial Stromal Sarcoma (ESS): Features favoring ESS include bilateral tumors, lack of endocrine manifestations, arteriolar vascular pattern, pericellular reticulin fiber network, and lack of staining with alpha-inhibin, FOXL2 and calretinin.
Undifferentiated Carcinoma: The diagnosis of undifferentiated carcinoma over adult GCT is favored by: nuclear hyperchromasia and pleomorphism, atypical mitoses, and absence of nuclear grooves. Adult GCT is positive for FOXL2, alpha-inhibin, calretinin, vimentin and negative for EMA. Adult GCT is confined to the ovary at presentation and has uniform nuclei with grooves.
The image shows ESS within vascular spaces.