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1:
Embryonal Carcinoma
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Comments: Embryonal carcinoma (EC) is usually seen in the setting of mixed germ cell tumor. Pure EC is uncommon. The tumor cells are arranged in tubular and glandular pattern and display vesicular nuclei with prominent nucleoli.
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2:
Embryonal Carcinoma
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Comments: Here the tumor cells are more closely packed in a sheet-like configuration. Numerous apoptotic cells and mitoses are visible.
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3:
Syncytiotrophoblast in Embryonal Carcinoma
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Comments: About 60% of cases of embryonal carcinoma contain syncytiotrophoblastic cells which are responsible for modest elevations of serum human chorionic gonadotropin. Ref: Javadpour N. The role of biologic tumor markers in testicular cancer. Cancer 45: 1755-1761, 1980.
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4:
Embryonal Carcinoma in Mixed Germ Cell Tumor
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Comments: Embryonal carcinomas are capable of producing a limited amount of immature stroma (as seen in this illustration). However, some authors would consider stromal component to represent immature teratoma and label such cases as mixed germ cell tumor (Embryonal carcinoma + immature teratoma).
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