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1:
Solitary Fibrous Tumor in Kidney
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Comments: It is a rare spindle cell neoplasm that was initially reported in the pleura, mediastinum, and lungs. Recently, many extrathoracic locations, including kidney and retroperitoneal soft tissue, have been described.
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2:
Solitary Fibrous Tumor in Kidney
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Comments: The tumor is composed of intersecting bundles of spindle-shaped cells with little atypia or mitotic activity. Some cases of solitary fibrous tumor have been associated with hypoglycemia due to abnormal secretion of insulin-like growth factors. Pathology International 1998; 48:47-52.
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4:
Solitary Fibrous Tumor : CD34
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Comments: Immunoreactivity for CD34 (shown here) and vimentin is usually seen. Am J Surg Pathol 20 (10): 1288-1295, 1996.
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5:
Leiomyosarcoma in Kidney
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Comments: Leiomyosarcoma is the most common primary renal sarcoma. Most patients are beyond 40 years of age; M:F = 2:1. The tumor is composed of intersecting fascicles of smooth muscle cells.
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6:
Leiomyosarcoma in Kidney
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Comments: This case shows minimal nuclear atypia. A mitotic figure is seen in the center of the image. The criteria for malignancy in smooth muscle neoplasms of kidney are not clearly defined. Large size, necrosis, nuclear pleomorphism, increased mitotic activity favor malignancy.
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7:
MFH in Kidney
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Comments: Primary MFH may arise in the renal parenchyma or in the renal capsule. More commonly, however, they arise in the retroperitoneal soft tissue and secondarily invade the kidney. They are large infiltrative tumors with a male predominance.
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8:
MFH in Kidney
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Comments: Most of MFH arising in the kidney are storiform-pleomorphic type as seen here. Distinction from sarcomatoid renal cell carcinoma may be difficult in some cases.
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9:
Angiosarcoma in Kidney
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Comments: Primary renal angiosarcoma is an extremely rare tumor with less than 2 dozen cases reported in the literature (Arch Pathol Lab Med 1998 Oct; 122(10):929-35). This illustration shows anastomosing vascular channels with minimal atypia in the lining endothelium.
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10:
Angiosarcoma in Kidney
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Comments: This illustration (same case as previous image) shows endothelial cells arranged in more compact sheets with abortive vascular spaces. Moderate cytologic atypia is seen.
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