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1:
Renal Cell Carcinoma : Gross Morphology
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Comments: This partial nephrectomy specimen shows the typical yellow-orange gross appearance commonly seen in renal cell carcinoma. However, on gross features alone, its distinction from angiomyolipoma and xanthogranulomatous pyelonephritis may be impossible. (Photo courtesy of: Dr. Kyle Molberg, UT Southwestern Med. Ctr, Dallas)
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3:
Renal Cell Carcinoma : Fuhrman Grade 1
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Comments: Fuhrman nuclear grading system correlated well with survival in patients with renal cell carcinoma. Grade 1 tumors have round, uniform nuclei with inconspicuous or absent nucleoli.
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6:
Cystic Renal Cell Carcinoma
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Comments: Note the cystic nature of this tumor. On gross appearance alone, it is impossible to distinguish this example of cystic RCC from other cystic lesions such as Multilocular cyst. (Photo courtesy of: Dr. Kyle Molberg, UT Southwestern Med. Ctr., Dallas)
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7:
Cystic Renal Cell Carcinoma
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Comments: Some cases of renal cell carcinoma are composed largely of multilocular cysts separated by thin septa containing tumor cells. The cystic nature of this tumor is illustrated in this low-power scan.
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8:
Cystic Renal Cell Carcinoma
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Comments: Many cystic spaces are filled with hemorrhage or proteinaceous fluid. Some authors require that at least 75% of the tumor be cystic to qualify as cystic RCC (Corica FA et al. J Urol 1999 Feb; 161 (2):408-11.
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9:
Cystic Renal Cell Carcinoma
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Comments: The tumor cells lining the septa have clear cytoplasm and small hyperchromatic nuclei. Cystic RCC has excellent prognosis with most patients being cured by resection, regardless of tumor size or stage. Nephron-sparing surgery such as partial nephrectomy may be appropriate in such cases.
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10:
Renal Cell Carcinoma : Dialysis patient
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Comments: Approximately 35% of patients on chronic dialysis develop Acquired Cystic Disease in their native kidneys. Renal cell carcinoma develops in approximately 6% of these patients. Arch Pathol Lab Med 1986 Jul; 110(7):592-601.
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