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1:
Papillary cystitis
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Comments: Proliferation of vessels and accumulation of edema fluid and inflammatory cells in the lamina propria has created papillary configuration focally. Distinction from papillary urothelial carcinoma is important.
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2:
Papillary cystitis
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Comments: Another example of papillary cystitis. The urothelium is hyperplastic. The lamina propria contains numerous plasma cells and delicate vessels.
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3:
Polypoid cystitis
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Comments: The term polypoid cystitis is applied for broad-based lesions enclosing large amounts of edema fluid with scattered inflammatory cells. If the lesions are even more broad-based and larger, the term bullous cystitis may be applied.
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4:
Polypoid cystitis
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Comments: The presence of edema fluid and inflammatory cells can be better appreciated in this image. The majority of the patients with polypoid cystitis have history of indwelling catheters.
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5:
Polypoid cystitis
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Comments: The lamina propria contains eosinophils, plasma cells, lymphocytes, and rare neutrophils. The overlying urothelium is unremarkable. On cystoscopic examination, papillary and polypoid cystitis are frequently mistaken for neoplasms. Microscopic examination reveals their true nature. Am J Surg Pathol 1988 Jul; 12(7):542-6.
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6:
Schistosomiasis
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Comments: Several eggs of Schistosoma hematobiumare seen embedded in the muscularis propria of this bladder surrounded by granulomatous response.
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7:
Schistosomiasis
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Comments: A single egg of Schistosoma hematobium is seen here surrounded by a cuff of eosinophils and other inflammatory cells. The terminal spine located at the lower right side of the egg is not well seen.
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8:
Eosinophilic cystitis in Schistosomiasis
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Comments: This is an example of Eosinophilic cystitis occurring in the setting of Schistosomiasis. Eosinophilic cystitis may also be associated with asthma, eosinophilic gastroenteritis, papillary urothelial carcinoma, or occur following transurethral resection.
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9:
Xanthogranulomatous cystitis
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Comments: This bladder biopsy shows sheets of lipid-laden macrophages interspersed with plasma cells and lymphocytes. Xanthogranulomatous cystitis may form tumor-like masses in the bladder and may be associated with benign or malignant tumors in the bladder or non-neoplastic conditions like diverticula. Histopathology 1998 Sept; 33(3):212-5.
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10:
Xanthogranulomatous cystitis
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Comments: The presence of other inflammatory cells besides macrophages is a helpful clue to the diagnosis of xanthogranulomatous cystitis. In difficult cases, the immunostain for CD-68 may be helpful.
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