Desmoplastic Small Round Cell Tumor : DESMIN

Immunohistochemically, intra-abdominal desmoplastic small round cell tumor shows concomitant expression of epithelial, mesenchymal, and neural markers. With desmin, it has perinuclear, dot-like positivity as seen in this image. Actin, myogenin, and MyoD1 are usually negative. Other markers that are negative include: calretinin, thrombomodulin, and CD99. Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission