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1:
Bladder - Condyloma
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Comments: The lesion consists of papillary or polypoid structures lined by hyperplastic, metaplastic squamous epithelium. Koilocytic haloes, resinoid nuclear changes, bi- or multinucleated cells, and dyskeratocytes are seen.
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2:
Bladder - Condyloma
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Comments: Isolated bladder involvement by condyloma is exceedingly rare. Most bladder condylomas occur in patient with long-standing anogenital lesions that have responded poorly to treatment and spread to urethra, bladder, and distal ureters. J Urol 1985 Mar; 133(3):465-7
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3:
Bladder - Condyloma
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Comments: Small discrete lesions can be managed by transurethral resection. Larger or more diffuse lesions require radical surgery.
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4:
Squamous Cell Carcinoma
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Comments: Most patients with squamous cell carcinoma of the bladder have history of chronic cystitis secondary to calculi, infection, schsistosomiasis, or cyclophosphamide chemotherapy. In the middle east, where schistosomiasis is common, majority of the bladder cancers are squamous cell carcinomas.
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5:
Squamous Cell Carcinoma
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Comments: Both the previous and current photomicrographs show the usual histologic features of moderately differentiated squamous cell carcinoma. They generally have poor prognosis due to advanced stage at presentation, but stage for stage, their prognosis is similar to urothelial carcinoma.
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6:
Sarcomatoid Squamous Cell Carcinoma
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Comments: Another case of squamous cell carcinoma arising in the bladder. This case shows sarcomatous transformation. Foci of typical squamous cell carcinoma in the center are surrounded by undifferentiated spindle cell sarcoma.
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7:
Sarcomatoid Squamous Cell Carcinoma
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Comments: Sarcomatoid carcinomas of the bladder are high-grade lesions whose prognosis depends upon the depth of invasion. This illustration is from a patient with bladder diverticulum who developed sarcomatoid carcinoma with areas of moderate to poorly differentiated squamous cell carcinoma.
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8:
Sarcomatoid Squamous Cell Carcinoma
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Comments: In this field, the lesion shows undifferentiated spindle cell pattern and is not recognizable as squamous cell carcinoma. True sarcomas of bladder are rare; tumors of bladder with undifferentiated spindle cell pattern are more likely to be of epithelial origin than of mesenchymal origin.
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9:
Verrucous Carcinoma
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Comments: Majority of the cases of verrucous carcinoma of the bladder have occurred in association with schistosomiasis or condyloma acuminata. The lesion has papillary and polypoid configuration consisting of well-differentiated keratinizing squamous epithelium. Note the “pushing” margins at its interface with lamina propria.
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10:
Verrucous Carcinoma
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Comments: Verrucous carcinoma of the bladder, like its counterpart in other locations, is a very low-grade indolent tumor; however, it is can cause significant morbidity and even death.
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11:
Verrucous Carcinoma
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Comments: Verrucous carcinoma is characterized by low-grade cytology and lacks significant atypia or mitotic activity as seen here. In one study, 3 cases of verrucous carcinoma of bladder were negative for HPV DNA, were aneuploid, and showed immunoreactivity for p53. Cancer 2000; 88:1679-86.
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