Keratinizing Squamous Metaplasia
This bladder biopsy is from a 78 y/o male with history of repeated urinary tract infections and urinary obstruction. Cystoscopy showed a whitish patch on the anterior bladder wall which was biopsied. Sections revealed keratinizing squamous metaplasia with hyperkeratosis and a granular cell layer. Keratinizing squamous metaplasia is a risk factor for development of squamous cell carcinoma and requires close follow-up.