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Clinical Features: Spindle cell/pleomorphic lipomas are most commonly seen in the 45-60 yr. age group with a strong male predilection (>90% of cases). They are rare in children or adolescents.

About 80% of cases arise in the subcutaneous tissues of the posterior neck, shoulder, or upper back. Rare cases are entirely intramuscular. About 20% of cases involve limbs, face, trunk, perineum, mediastinum, larynx, orbit, and oral cavity. Lesions in women, although rare, often tend to be dermal, occur at younger age, and involve atypical sites mentioned above.

They present as a slow-growing, solitary, well-circumscribed, firm, painless subcutaneous nodules. Rare cases have multiple lesions some of which are familial. The multiple lesions may be synchronous or metachronous.

About this image: A large spindle cell lipoma arising in the posterior neck of a 55 y/o male. The lesion had been slowing enlarging over last 20 years. Image source: Machol, J. A., et al. (2015). Spindle Cell Lipoma of the Neck. Plastic and Reconstructive Surgery - Global Open. 3. 1. 10.1097/GOX.0000000000000405. Used under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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