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Introduction: Spindle cell lipoma and pleomorphic lipoma are uncommon benign lipomatous tumors that show overlapping clinical, histologic, immunohistochemical, and cytogenetic features (monosomy or partial loss of 13q or 16q). Some cases show features of pure spindle cell or pure pleomorphic lipoma. Others have areas of both within the same tumor. They appear to represent morphologic continuum of the same entity. They should not be confused with atypical lipomatous tumor/well-differentiated liposarcoma.

This image of spindle cell lipoma shows an admixture of bland spindle cells and mature univacuolated adipocytes.
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Image 1 of 36