Image Description
Myxoid Liposarcoma, High-Grade (Round Cell LPS): The tumor cells are larger, primitive-appearing with a high nucleus/cytoplasm ratio, a prominent nucleolus and scant cytoplasm. They are arranged back-to-back in compact sheets without much myxoid stroma, imparting a basophilic appearance at low magnification.
The tumor cells may also form trabeculae or cords. Lipoblasts and plexiform capillary network are less prominent than myxoid LPS. The percentage of high-grade areas should be documented in the pathology report. The tumor may be combined myxoid and round cell LPS or pure round cell LPS. The high-grade areas harbor the same translocations as myxoid LPS.
The tumor cells may also form trabeculae or cords. Lipoblasts and plexiform capillary network are less prominent than myxoid LPS. The percentage of high-grade areas should be documented in the pathology report. The tumor may be combined myxoid and round cell LPS or pure round cell LPS. The high-grade areas harbor the same translocations as myxoid LPS.