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Gemistocytic astrocytoma is a low-grade astrocytoma with poorer prognosis than other WHO grade matched tumors. They show a higher rate of progression to glioblastoma and some authors suggest they should be considered WHO Grade III tumors. The histologic hallmark is the presence of gemistocytes - large tumor cells with abundant dense eosinophilic, GFAP-positive cytoplasm displacing the nucleus eccentrically.