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Hypopigmented Mycosis fungoides (MF): MF may rarely be associated with hypopigmentation, especially in children and adolescents. It is more readily apparent in dark-skinned individuals. Clinically, it can resemble vitiligo, pityriasis alba, tinea versicolor, and postinflammatory hypopigmentation.
The lesions appear on trunk and extremities as slightly scaly, hypopigmented patches that may be asymptomatic or slightly pruritic. It pursues an indolent course with an excellent prognosis.
Microscopically and immunophenotypically, hypopigmented MF resembles typical MF but shows prominent pigment incontinence. Epidermotropism is striking. The pathogenesis of hypopigmented MF is not fully understood. It may represent a non-specific response to cellular injury. There is no evidence of blocking of melanosome transfer to keratinocytes.
The lesions appear on trunk and extremities as slightly scaly, hypopigmented patches that may be asymptomatic or slightly pruritic. It pursues an indolent course with an excellent prognosis.
Microscopically and immunophenotypically, hypopigmented MF resembles typical MF but shows prominent pigment incontinence. Epidermotropism is striking. The pathogenesis of hypopigmented MF is not fully understood. It may represent a non-specific response to cellular injury. There is no evidence of blocking of melanosome transfer to keratinocytes.