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Granulomatous Mycosis Fungoides (MF) - Differential Diagnosis: There is considerable histologic overlap between granulomatous MF and granulomatous slack skin disease - which is a specific type of MF.
Features favoring granulomatous slack skin disease include: dense lymphocytic infiltrate extending into subcutis, ill-defined granulomas, prominent lymphophagocytosis, multinucleate giant cells with numerous nuclei, and more extensive loss of elastic tissue.
Granulomatous inflammation can also be a feature of many subtypes of cutaneous B- and T-cell lymphomas.
Features favoring granulomatous slack skin disease include: dense lymphocytic infiltrate extending into subcutis, ill-defined granulomas, prominent lymphophagocytosis, multinucleate giant cells with numerous nuclei, and more extensive loss of elastic tissue.
Granulomatous inflammation can also be a feature of many subtypes of cutaneous B- and T-cell lymphomas.