Image Description
Lymphocyte-rich Classic Hodgkin Lymphoma: The nodular variant of lymphocyte-rich classic Hodgkin lymphoma is composed predominantly of B cells. Regressed germinal centers, similar to those seen in Castleman disease, may be present. The neoplastic cells - classic Reed-Sternberg cells - are scattered singly in the expanded mantle zones. Other inflammatory cells such as eosinophils, neutrophils, and plasma cells are rare.
Cells resembling LP cells with folded or multilobated nuclei (a feature usually seen in nodular lymphocyte-predominant Hodgkin lymphoma) may be present. Two LP-like cells are present in this image. CD30 and CD15 immunohistochemistry is quite helpful in distinguishing these cases from NLPHL. LP cells of NLPHL are negative for both CD30 and CD15.
About the Disease
Classic Hodgkin lymphoma (cHL) is an uncommon malignant neoplasm of germinal-center B-cell origin that is primarily seen in young adults and, less commonly, in elderly patients. It usually arises in a single node or group of nodes and shows orderly spread to contiguous lymphoid tissues. The neoplastic cells - known as Hodgkin and Reed-Sternberg cells - make up only about 1% of all the cells in the involved lymph node or tissue. They express cell surface CD30 antigen and are present in a microenvironment rich in immune effectors cells. Four histologic subtypes are recognized in the current classification - nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted. In about 5% of cases, a subtype cannot be specified due to insufficient material for a complete analysis. The prevalence of Epstein-Barr virus and its role in the pathogenesis depends upon the subtype. cHL is highly sensitive to radiation and chemotherapy and is characterized by a high cure rate, even in advanced stages. Several novel therapies targeting specific molecular pathways have been developed to treat refractory cases. The comments accompanying the images have been derived from the following sources: References:Jaffe, E. S. et al (2017). Hematopathology - Second Edition. Philadelphia, PA. Elsevier. Goldblum, J. R. et al (2018). Rosai and Ackerman's Surgical Pathology - 11th Edition. Philadelphia, PA. Elsevier. Kumar, V., Abbas, A. K., & Aster, J. C. (2021). Robbins and Cotran Pathologic Basis of Disease - Tenth Edition. Philadelphia, PA. Elsevier. Connors, J. M. et al. Hodgkin Lymphoma. Nature Reviews. Disease Primers (2020) 6:61. Kuppers R, Engert A, & Hansmann M. Hodgkin Lymphoma. J Clin Invest. 2012; 122(10):3439-3447.