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Microscopic Features of Hyaline-Vascular Castleman Disease (HVCD): HVCD makes up 90% of cases of Castleman Disease. The remaining 10% are plasma cell type.
HVCD is characterized by numerous small, regressively transformed germinal centers surrounded by an expanded mantle zone and a vascular proliferation in the interfollicular region. Sinuses are inconspicuous or absent. There are bands of fibrosis especially in pericapsular and perivascular regions.
HVCD is characterized by numerous small, regressively transformed germinal centers surrounded by an expanded mantle zone and a vascular proliferation in the interfollicular region. Sinuses are inconspicuous or absent. There are bands of fibrosis especially in pericapsular and perivascular regions.