Ovarian Cancer : BRCA Mutations
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Majority of the ovarian cancers associated with BRCA mutations are high-grade serous type. Other histologic types are sometimes seen in these patients.
In contrast to the classic sporadic high-grade serous carcinomas, the BRCA-associated cases are more likely to show a combination of certain clinical and histologic features as follows: younger age, undifferentiated foci, solid/endometrioid/transitional growth patterns, lower frequency of papillary/micropapillary areas, lower frequency of serous tubal intraepithelial carcinoma, numerous tumor infiltrating lymphocytes, very high mitotic rate, and extensive comedonecrosis.
In contrast to the classic sporadic high-grade serous carcinomas, the BRCA-associated cases are more likely to show a combination of certain clinical and histologic features as follows: younger age, undifferentiated foci, solid/endometrioid/transitional growth patterns, lower frequency of papillary/micropapillary areas, lower frequency of serous tubal intraepithelial carcinoma, numerous tumor infiltrating lymphocytes, very high mitotic rate, and extensive comedonecrosis.