Juvenile Granulosa Cell Tumor : Intro & Clinical
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
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Introduction: Juvenile granulosa cell tumor (JGCT) of the testis is a rare tumor that is composed of cystic structures resembling Graafian follicles. It is morphologically similar to its ovarian counterpart.
Epidemiology: It comprises < 0.5% of all testicular sex cord-stromal tumors (all ages included); however, it is the most common congenital testicular neoplasm. About 50% of cases are detected in the neonatal period and almost 90% of cases occur within the first year of life. It makes up between 3% to 6% of all prepubertal testicular tumors.
Clinical Features: It usually presents as a painless testicular mass that is not hormonally active. Most cases pursue a benign course. It can be associated with gonadal dysgenesis and cryptorchidism.
This low power view shows lobular growth pattern in a JGCT.
Epidemiology: It comprises < 0.5% of all testicular sex cord-stromal tumors (all ages included); however, it is the most common congenital testicular neoplasm. About 50% of cases are detected in the neonatal period and almost 90% of cases occur within the first year of life. It makes up between 3% to 6% of all prepubertal testicular tumors.
Clinical Features: It usually presents as a painless testicular mass that is not hormonally active. Most cases pursue a benign course. It can be associated with gonadal dysgenesis and cryptorchidism.
This low power view shows lobular growth pattern in a JGCT.