Regressed Germ Cell Tumor : Intro
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
Introduction: Testicular germ cell tumors (GCTs) can undergo partial or complete regression spontaneously in the absence of any treatment - a phenomenon seen in less than 5% of cases.
Regression can occur in all types, although it is most frequently seen in seminomas. Many pure teratomas with mature elements are in fact mixed germ cell tumors in which the non-teratomatous components regressed. The regressed tumor is replaced by a discrete fibrous nodule or scar. Such cases are also referred to as "burnt-out" germ cell tumors.
The image of a regressed GCT shows a well-defined scar (lower right), tubular atrophy (upper right), and an angiomatous focus (upper left).
Regression can occur in all types, although it is most frequently seen in seminomas. Many pure teratomas with mature elements are in fact mixed germ cell tumors in which the non-teratomatous components regressed. The regressed tumor is replaced by a discrete fibrous nodule or scar. Such cases are also referred to as "burnt-out" germ cell tumors.
The image of a regressed GCT shows a well-defined scar (lower right), tubular atrophy (upper right), and an angiomatous focus (upper left).