Mixed Germ Cell Tumor : Clinical
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
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Clinical Features of Mixed Germ Cell Tumors (MGCTs): As with other nonseminomatous germ cell tumors, the patients usually present with a testicular mass. The average age at diagnosis is 30 years. They are extremely rare in prepubertal patients. Serum tumor markers (LDH, alpha-fetoprotein, beta-hCG) are frequently elevated and reflect the components present.
The pathology report should list all the components and their approximate percentages since it may influence the prognosis, especially in clinically Stage 1 patients. This MGCT from a 38 y/o male was composed of embryonal carcinoma (about 70% of the tumor; large variegated nodule with necrosis in the center of the testis) and seminoma (about 30%; multiple homogenous pink-tan nodules near the upper pole of the testis).
The pathology report should list all the components and their approximate percentages since it may influence the prognosis, especially in clinically Stage 1 patients. This MGCT from a 38 y/o male was composed of embryonal carcinoma (about 70% of the tumor; large variegated nodule with necrosis in the center of the testis) and seminoma (about 30%; multiple homogenous pink-tan nodules near the upper pole of the testis).