Juxtaglomerular Cell Tumor

Juxtaglomerular cell tumor is a benign renal tumor that usually presents in young adults with a slight female predominance. Most cases show elevated renin production resulting in hypertension that is corrected surgically with the removal of the tumor. Some tumors are non-functioning. Most cases are unilateral, solitary, small (usually less than 3 cm) and located in the cortex. The tumor cells are monomorphic and may be arranged in sheets (shown here), anastomosing cords, or trabecular structures. Vasculature is well-developed and consists of small venules, muscular arterioles, and capillaries interposed between tumor cells.