Fibrolamellar Carcinoma of Liver

FLC is distinguished from conventional HCC by unique histologic features, namely: parallel fibrous lamellae separate cords and clusters of large, polygonal, densely eosinophilic tumor cells with distinctive granular cytoplasm and large nuclei. The fibrotic stroma resembles that of the scirrhous pattern of conventional HCC but, in FLC, is present throughout the tumor in dense, parallel lamellae. Higher magnification of the previous image.