Hepatocellular Carcinoma

Putative precursors of HCC include: large-cell liver dysplasia (large-cell change), small-cell liver dysplasia (small-cell change), macroregenerative nodule (adenomatous hyperplasia, large regenerative nodule, Type I MRN), dysplastic nodule low/high grade (borderline lesion, Type II MRN), and dysplastic foci (<1 mm diameter). Macroregenerative nodules (MRN), as seen here, develop in cirrhotic liver or other chronic liver disease and are usually >0.8 cm. MRN are common in cirrhosis and may co-exist with HCC or contain foci of HCC.