Hepatocellular Carcinoma
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Approximately 85% of HCCs develop in cirrhotic liver. Cirrhosis-associated carcinoma is usually macronodular, except for the micronodular cirrhosis seen in genetic hemochromatosis and chronic hepatitis C infection. The involvement in cirrhotic liver is usually more diffuse (as seen here) than the tumors occurring in non-cirrhotic livers. HCC in non-cirrhotic liver may be attributed to hepatitis B carrier status, occult hepatitis B infection, or hepatitis C infection.