Adenosquamous Carcinoma of Gallbladder
Image Description
Adenosquamous Carcinoma of Gallbladder: This is another example of adenosquamous carcinoma of gallbladder. The glandular component is on the left and it had areas reminiscent of intracholecystic papillary-tubular neoplasm. The squamous component is invasive and seen on the right and bottom on the image.
Some squamous cell carcinomas of gallbladder have a predominant spindle cell pattern and may be mistaken for high-grade sarcomas. Immunostains may be unhelpful in separating them due to overlapping features. Squamous cell carcinomas of gallbladder usually present at higher stage and have worse prognosis than conventional adenocarcinomas.
Some squamous cell carcinomas of gallbladder have a predominant spindle cell pattern and may be mistaken for high-grade sarcomas. Immunostains may be unhelpful in separating them due to overlapping features. Squamous cell carcinomas of gallbladder usually present at higher stage and have worse prognosis than conventional adenocarcinomas.