Neuroblastoma : Poorly-differentiated

Poorly-differentiated neuroblastoma is composed of typical neuroblasts and 5% or less of the tumor shows differentiation toward mature ganglion cells. It is the most commonly seen pattern in neuroblastoma group. The tumor shows neuropil and Homer-Wright rosettes consisting of an arrangement of tumor cells around a central area (not a lumen, canal, or a blood vessel) filled with neurofibrillary processes. A few rosettes can be seen in the right one-third of this image.