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Enteropathy-associated T-cell lymphoma (EATL): The neoplastic T-cells form a dense infiltrate with destruction of the native architecture. They are moderately pleomorphic, medium-to-large size with round or angulated nuclei and prominent nucleoli.

About 40% of cases show large cell or anaplastic phenotype. The tumor cells display angiocentric and angioinvasive pattern with extensive necrosis. There is a prominent component of inflammatory cells, including histiocytes and eosinophils. Note the intraepithelial lymphocytes.

For a more complete discussion of microscopic features, go to Slide 3.

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