Radiation Changes : Benign Prostate
Higher magnification of a post-brachytherapy prostate biopsy showing marked cytologic atypia. The nuclei are irregularly enlarged and show scattered prominent nucleoli. Some of the cells show degenerative type changes including intranuclear and cytoplasmic vacuolization. This degree of cytologic atypia would be highly unusual for adenocarcinoma and when present would be more uniform throughout the malignant glands.