Chondroid Lipoma : Clinical Features

Clinical Features: Chondroid lipoma usually develops in the 3rd or 4th decade of life (age range 15 to 70 years; median 36 years). There is a strong female predilection (F:M = 4:1). It presents as a slow growing, painless mass of long duration. The most common location is proximal limbs or limb girdles and less commonly on the trunk or head and neck region (especially oral cavity and nasopharynx). The lesions may be superficial or deep and can occur in the subcutis, superficial fascia, or entirely within the skeletal muscles.

This image shows an admixture of mature adipocytes, uni- or multivacuolated lipoblasts and hibernoma-like cells with eosinophilic granular cytoplasm. Image courtesy of: Andy Zhang, MD, Dept. of Pathology, Rushan People's Hospital, Rushan City, Shandong Province, China.