Post-atrophic Hyperplasia : HMWCK + p63
The distinction of post-atrophic hyperplasia from adenocarcinoma usually does not pose a diagnostic challenge. In rare cases with somewhat overlapping features, immunostaining with basal cell-specific markers can help. The image shows strong staining with high molecular weight cytokeratin and p63 in a focus of post-atrophic hyperplasia. Note the lobular arrangement of the glands.