At low magnification, the complex papillary folds and irregular branching lumens of seminal vesicular mucosa become evident. Abundant golden-brown granules of lipofuscin pigment are present. Compare this image with next slide from the seminal vesicle of a relatively young man (age 45 yrs). Seminal vesicular epithelium lacks immunoreactivity for PSA and PAP and shows basal cells with high molecular weight cytokeratin and p63 markers. These are helpful features in distinguishing them from prostatic adenocarcinoma when there is diagnostic dilemma in limited specimens such as needle biopsies.