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Neuroblastoma : Bone Marrow Metastasis

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Bone marrow evaluation is a routine part of clinical staging of neuroblastomas and in monitoring disease activity. Bone marrow metastases usually take the form of paratrabecular nests of poorly-differentiated neuroblasts with little or no neuropil in the background. In post-chemotherapy bone marrow specimens, one often sees differentiating neuroblasts, singly or in small clusters, with abundant neuropil. Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission

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