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Spindle Cell Lipoma : Gross Pathology

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Gross Features: Spindle cell/pleomorphic lipomas are usually well-circumscribed, solitary nodules that are easily demarcated from the surrounding subcutaneous tissues (as seen in this case). Their gross appearance depends upon the relative proportion of mature adipose tissue and spindle cell areas.

Some tumors are composed largely of mature adipose tissue with small foci of spindle or pleomorphic cells. They resemble ordinary lipomas with scattered grey-white gelatinous or firm areas corresponding to the spindle cell component. Other cases are devoid of fat and are predominantly or entirely composed of spindle/pleomorphic cells (fat-free spindle cell lipomas). They appear grey-white with gelatinous or firm consistency.

Rare cases, usually arising in women and located in the dermis, are less circumscribed.

Image courtesy of: Bin Xu, MD, Dept. of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY; used with permission.

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