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Follicular Dendritic Cell Sarcoma : Gross

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Gross Pathology of Follicular Dendritic Cell Sarcoma (FDCS): The size ranges from 1 cm (usually involving cervical lymph nodes) to as much as 15-20 cm (involving retroperitoneum or mediastinum). The median size is about 5 cm. Tumor is well-circumscribed with a solid, pink-tan and homogenous surface. Areas of hemorrhage or necrosis may be present in larger tumors.

This image shows FDCS arising in colon. There is proliferation of a uniform population of spindle cells in fascicular, storiform, and whorled patterns. The spindle cells are admixed with an inflammatory infiltrate of small lymphocytes and plasma cells.

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