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Neuroblastoma : Introduction

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Neuroblastoma is the most common extra-cranial solid tumor in childhood. It is exceeded in incidence only by acute leukemias and primary brain tumors (mainly astrocytoma and medulloblastoma). Neuroblastoma and its related tumors ganglioneuroblastoma and ganglioneuroma are of neural crest origin and they represent a continuum both at the morphologic level as well as at the level of gene expression. Neuroblastoma represents the malignant undifferentiated end and ganglioneuroma represents the fully-differentiated benign end of the spectrum. The image shows a multinodular, grayish, well-circumscribed tumor in the adrenal medulla arising in a 1 year old female. Histology showed neuroblastoma, Schwannian stroma-poor, poorly differentiated subtype (more on histologic grading in later slides). Image copyright: pathorama.ch.

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