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Small Cell Carcinoma : Gross

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Small cell lung carcinoma (SCLC) makes up between 10-20% of all lung cancers. Among all lung cancers, it has the strongest association with smoking. Only 1% of cases occur in non-smokers. Most patients are males and the median age at diagnosis is 60 years. Onset of symptoms/signs is generally rapid due to tumor growth, extrapulmonary spread, and paraneoplastic syndromes.

Gross: Most cases arise centrally near major bronchi. About 5% of tumors involve lung periphery. Grossly, SCLC presents as a bulky perihilar mass with nodal involvement (yellow arrows; note the anthracotic pigment). It may show subepithelial spread along the bronchi. The cut surface is white-tan, soft, and friable and may have a necrotic center. Image copyright: pathorama.ch

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