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Basaloid Squamous Cell Carcinoma

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Basaloid squamous cell carcinoma (BSCC) of lung is a distinct high-grade poorly-differentiated variant that lacks obvious squamous morphology (keratinization, keratin pearls, intercellular bridges) but expresses squamous cell markers (p40, p63) by immunohistochemistry. The tumor cells have a basophilic appearance and are arranged in lobules with peripheral palisading. Tumors with obvious squamous differentiation but a majority basaloid component (>50%) are also classified as BSCC.

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