The ductules may have discrete round or oval profiles or they may form complex plexiform structures of fused acini. The lining epithelium is cuboidal or low columnar with a central large nucleus, prominent nucleolus, and moderate amount of pale granular cytoplasm. Chronic inflammation and fibrosis are frequently present nearby. The proliferating ductules of vasitis nodosa may be mistaken for prostatic adenocarcinoma. Benign vascular invasion (Ref: Balogh K, Travis WD. Am J Clin Pathol 1985 Apr; 83(4):426-30) or even perineural invasion of nerves of the spermatic cord may be seen further complicating interpretation in some cases. Goldman RL, Azzopardi JG. Histopathology 1982 May; 6(3):309-15.