Gout is a crystal-induced arthropathy caused by deposition of monosodium urate crystals into the joints. It usually affects small bones of hands and feet, especially the metatarsophalangeal joints. The deposition of crystals eventually destroys the articular cartilage, bone and the ligaments severely limiting the joint function. The image shows gouty tophi in peri-articular soft tissue surrounded by histiocytes and foreign body giant reaction.
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