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Ewing Sarcoma

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High power view showing sheets of small, uniform cells with scant cytoplasm, round nuclei, and small punctate nucleoli. Most cases (~ 95%) of ES/PNET show a reciprocal translocation t(11;22)(q24;q12) or t(21;22)(q22;q12) resulting in the fusion of EWS gene with FLI1 or ERG gene, respectively. Image courtesy of: Dr. Ed Uthman, Houston, Texas

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