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GCNIS : Pagetoid Spread to Rete Testis

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Rete testis showing pagetoid spread of germ cell neoplasia in situ (GCNIS) from nearby tubules. The invasive component in this case was a seminoma. In one study, pagetoid spread of GCNIS to rete testis was seen in 28% of seminomas and in 49% of non-seminomatous germ cell tumors (Perry A, Wiley EL, Albores-Saavedra J. Hum Pathol. 1994 Nov; 25(11):1256-7.) Another study reported this phenomenon in 14 of 47 cases (29.7%) of germ cell tumors. Lee AH, Theaker JM. Histopathology. 1995 Oct; 27(4):391-2.

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