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Hepatoblastoma is typically a solitary, well-demarcated mass arising in noncirrhotic liver parenchyma. As in hepatocellular carcinoma, hemorrhage, necrosis, and bile-staining may be prominent. Almost all hepatoblastomas express alpha fetoprotein. There is marked size variation as tumors often present late with non-specific symptoms. Multinodular tumors may contain different histologic components and should be adequately sampled. Following chemotherapy, there is often abundant necrosis and only mesenchymal components may remain viable. Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission

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