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Focal Nodular Hyperplasia

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High power view: the fibrous stroma typically contains bile ductular structures, which can be highlighted by cytokeratin 7, and a chronic inflammatory infiltrate. Hepatocytes at the stromal interface may show mild reactive atypia with enlarged nuclei and prominent nucleoli. Foci of marked atypia or increased mitotic activity suggest an alternative diagnosis, such as atypical liver cell adenoma or hepatocellular carcinoma.

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