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Cirrhosis in Tyrosinemia

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Tyrosinemia type I (hereditary infantile tyrosinemia) is caused by a deficiency of the enzyme fumarylacetoacetate hydrolase and invariably results in cirrhosis, which is the histologic hallmark of the disease. Nodules > 3 mm are designated “macronodular cirrhosis” (as seen here) while those < 3 mm are “micronodular.” Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission

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