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Paraganglion in Prostate Biopsies - Immunoreactivity for Synaptophysin

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Comments:
When present in prostate needle biopsies, paraganglia must be distinguished from high-grade prostatic adenocarcinoma. Prominent vascular pattern, degenerative atypia, lack of immunoreactivity for PSA and PSAP, strong immunoreactivity for neuroendocrine markers (image shows positivity for Synaptophysin), presence of sustentacular cells with S-100 protein favor paraganglion. Kawabata K. Arch Pathol Lab Med. 1997;121:515-516

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