Intraductal Papillary Neoplasm of Bile Duct : Clinical Features

Comments:
Clinical Features of Intraductal Papillary Neoplasm of Bile Duct (IPNB): Most patients are between 50 and 70 years of age with a slight male predilection. The clinical features include intermittent abdominal pain, jaundice and acute cholangitis. About 12%-15% of cases are asymptomatic and detected incidentally. In the Far Eastern countries, about 30% of patients have gallstones (concomitant or past history).

Furthermore, IPNB in Asian patients is more likely to be intrahepatic and less often invasive than in patients from Western countries. Associated conditions include hepatolithiasis, primary sclerosing cholangitis, and liver fluke infections (Opisthorchis viverrini, Clonorchis sinensis). On cholangiography, IPNB appears as filling defects in the biliary tract due to polypoid tumor and mucin filling up the duct.

The image shows an IPNB with arborizing papillary and villous architecture.