Intraductal Papillary Neoplasm of Bile Duct : Immunophenotype

Comments:
Immunophenotype: Intraductal papillary neoplasms of the bile duct (IPNBs) express various markers in accordance with the cell types. Pancreatobiliary express MUC1. Intestinal types express MUC2 (shown here), CK20, and CDX2. Gastric types express MUC5AC, MUC6, and CK7. The expression of SMAD4 is usually retained.

The image shows intestinal type of IPNB with MUC2 expression. Note the goblet cells. Image source: Nakanuma Y. et al. Intraductal Papillary Neoplasm of Bile Duct: Updated Clinicopathologic Characteristics and Molecular and Genetic Alterations. J. Clin. Med. 2020, 9, 3991; doi:10.3390/jcm9123991; image cropped and used under Creative Commons Attribution License.