Intraductal Papillary Neoplasm of Bile Duct : Low-grade Dysplasia

Comments:
Dysplasia in Intraductal Papillary Neoplasm of the Bile Duct (IPNB): Neoplastic cells in IPNBs show cytoarchitectural changes ranging from none (normal) to low-grade dysplasia to high-grade dysplasia/carcinoma-in-situ to stromal invasion. Most IPNBs arising in extrahepatic bile ducts show high-grade dysplasia.

Low-grade Dysplasia in IPNB: Foci with low-grade dysplasia have mild architectural and cytologic changes (as shown in this image). The nuclei may be slightly enlarged and show some hyperchromasia but are still relatively uniform in shape. The nuclei maintain polarity and are mostly confined to the basal portion of the epithelium. Nucleoli are inconspicuous or small.