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Extranodal Rosai-Dorfman Disease : Testis

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Rosai-Dorfman disease (RDD) of the testis. The image shows a mixed infiltrate of histiocytes, lymphocytes and plasma cells in the interstitium in between atrophic seminiferous tubules. Some of the histiocytes (larger multinucleated-appearing cells near the center) show emperipolesis.

The differential diagnosis of testicular RDD is granulomatous orchitis, hematolymphoid disorders, germ cell tumors, and metastases.

Image courtesy of: Andres Matoso, MD, Dept. of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA; used with permission.

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